About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:4867520
Allelic
Composition
Clockm1Jt/Clockm1Jt
Genetic
Background
involves: BALB/cJ * C57BL/6 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Clockm1Jt mutation (3 available); any Clock mutation (34 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• nucleus accumbens medium spiny neurons have longer and more complex dendrites and exhibit reduced GluR1 expression than those of wild-type mice
• lithium treatment reverses the changes in dendritic morphology
• nucleus accumbens medium spiny neurons have longer and more complex dendrites and exhibit reduced GluR1 expression than those of wild-type mice
• phase coupling between nucleus accumbens low-gamma oscillatory activity and delta activity is disrupted and prelimbic cortex low-gamma cross-frequency phase coupling tends to be decreased
• mutant mice fail to display the nucleus accumbens low-gamma cross-frequency phase coupling observed in wild-type mice during behaviorally immobile periods
• mutants exhibit neuronal entrainment deficits in nucleus accumbens
• lithium treatment ameliorates the nucleus accumbens phase-signaling dysfunction

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
bipolar disorder DOID:3312 J:166742


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
12/03/2019
MGI 6.14
The Jackson Laboratory