Mouse Genome Informatics
tg
    Tg(CAG-ELN*)60Zu/0
C57BL/6J-Tg(CAG-ELN*)60Zu
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
respiratory system
• apoptosis in the lungs is elevated
• lung elastic recoil pressure is reduced
• elastic modulus (stiffness) of lung tissue is decreased
• at all lung volumes, lungs have greater compliance than non-transgenic mice

cardiovascular system
• mutant elastin is not incorporated into the elastic fibers of the aorta

integument
• mutant elastin is not incorporated into the elastic fibers of the skin

Mouse Models of Human Disease
OMIM IDRef(s)
Cutis Laxa, Autosomal Dominant 1; ADCL1 123700 J:166809