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Phenotypes Associated with This Genotype
Genotype
MGI:4867519
Allelic
Composition
Tg(CAG-ELN*)60Zu/0
Genetic
Background
C57BL/6J-Tg(CAG-ELN*)60Zu
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
respiratory system
• apoptosis in the lungs is elevated
• lung elastic recoil pressure is reduced
• elastic modulus (stiffness) of lung tissue is decreased
• at all lung volumes, lungs have greater compliance than non-transgenic mice

cardiovascular system
• mutant elastin is not incorporated into the elastic fibers of the aorta

integument
• mutant elastin is not incorporated into the elastic fibers of the skin

Mouse Models of Human Disease
OMIM ID Ref(s)
Cutis Laxa, Autosomal Dominant 1; ADCL1 123700 J:166809


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/12/2016
MGI 6.04
The Jackson Laboratory