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Phenotypes Associated with This Genotype
Genotype
MGI:4867515
Allelic
Composition
Tg(DYRK1A)36Wjs/0
Genetic
Background
involves: C57BL/6NCrjBgi
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(DYRK1A)36Wjs mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• in the Morris water maze with hidden platform, mutants do not show any improvement in finding the hidden platform during training, even after repeated training for 8 days, indicating severe spatial memory impairment
• in probe trials, where the platform was removed after the 4th, 6th, and 8th day of training, mutants do not show any improvement with training, indicating that mice do not learn the location of the platform
• mutants show a slight delay in balancing during rotarod training at the first trial but they maintain their balance in subsequent training sessions
• however, no other motor abnormalities are apparent

nervous system
• embryonic neocortical neuronal cells at E14.5 exhibit impaired proliferation
• primary cortical neural stem cell precursors from E12.5 embryos exhibit impaired proliferation
• 19% increase in brain weight at 9 weeks of age, however body weights were no different from controls
• altered bidirectional synaptic plasticity, with a shift in plasticity toward a greater induction of long term potentiation (LTP) and a lesser induction of long term depression (LTD)
• basal synaptic transmission is normal
• theta-burst stimulation at 100 Hz yields a greater increase in LTP than in controls
• stimulation at an intermediate frequency of 900 pulses at 10 Hz produces a modest enhancement of potentiation compared to controls
• magnitude of the LTD measured for 65 minutes after conditioning is higher than in controls
• LTD at paired-pulse low frequency stimulation is reduced in hippocampal slices

cellular
• embryonic neocortical neuronal cells at E14.5 exhibit impaired proliferation
• primary cortical neural stem cell precursors from E12.5 embryos exhibit impaired proliferation

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Down syndrome DOID:14250 OMIM:190685
J:111293


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/04/2018
MGI 6.13
The Jackson Laboratory