Phenotypes Associated with This Genotype

Genotype
MGI:4867512

• Allelic Composition: Soat1^ald/Soat1^ald
• Genetic Background: AKR/O

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

abnormal adrenal cortex morphology ( J:5089 , J:12157 )

• onset of adrenocortical lipid depletion takes place in mice between 30 and 40 days of age (J:5089)

• in males adrenocortical lipid depletion coincides roughly with adrenal X-zone degeneration and maturation of seminiferous epithelium (J:5089)

• adrenal cortex of males is totally depleted of lipid (J:12157)

• adrenal cortex of females is not totally depleted and lipid pattern is variable (J:12157)

• large doses of ACTH restores lipid concentration and distribution (J:12157)

abnormal adrenocortical cell morphology ( J:12157 )

• lipid vacuoles are sparse

• cells are enriched with mitochondria

thymus hyperplasia ( J:12157 )

• evident from birth

hematopoietic system

thymus hyperplasia ( J:12157 )

• evident from birth

immune system

thymus hyperplasia ( J:12157 )

• evident from birth

neoplasm

increased leukemia incidence ( J:12157 )

• high incidence of lymphatic leukemia