Phenotypes Associated with This Genotype

Genotype
MGI:4867291

• Allelic Composition: Gsk3b^tm1.1Ypc/Gsk3b^tm1.1Ypc; Tg(Pitx2-cre)1Ych/0
• Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

craniofacial

palatal shelves fail to meet at midline ( J:166721 )

• at E18.5 anterior shelves are in a horizontal position but fail to meet at the midline; posterior shelves remain in a vertical orientation

cleft secondary palate ( J:166721 )

• 11 of 14 mice show complete cleft of the secondary palate

failure of palatal shelf elevation ( J:166721 )

• at E14.5 the shelves remain in the vertical position and fail to elevate to the position above the tongue

digestive/alimentary system

palatal shelves fail to meet at midline ( J:166721 )

• at E18.5 anterior shelves are in a horizontal position but fail to meet at the midline; posterior shelves remain in a vertical orientation

cleft secondary palate ( J:166721 )

• 11 of 14 mice show complete cleft of the secondary palate

failure of palatal shelf elevation ( J:166721 )

• at E14.5 the shelves remain in the vertical position and fail to elevate to the position above the tongue

growth/size/body

palatal shelves fail to meet at midline ( J:166721 )

• at E18.5 anterior shelves are in a horizontal position but fail to meet at the midline; posterior shelves remain in a vertical orientation

cleft secondary palate ( J:166721 )

• 11 of 14 mice show complete cleft of the secondary palate

failure of palatal shelf elevation ( J:166721 )

• at E14.5 the shelves remain in the vertical position and fail to elevate to the position above the tongue