Phenotypes Associated with This Genotype

Genotype
MGI:4867251

• Allelic Composition: Zap70^m1Btlr/Zap70^m1Btlr
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:167119 , J:185495 )

N • mice display normal T-independent IgM responses to haptenated ficoll and serum levels of IgA (J:167119)

N • mice exhibit a normal response to NP-Ficoll (J:185495)

abnormal class switch recombination ( J:185495 )

• mice exhibit reduced class-switch antibody response in response to recombinant Semliki Forest virus (SFV) encoded antigen compared with control mice

decreased T cell number ( J:185495 )

• severe T cell deficiency

absent CD4-positive, alpha-beta T cells ( J:167119 )

absent CD8-positive, alpha-beta T cells ( J:167119 )

abnormal humoral immune response ( J:167119 )

• mice lack a T-dependent immuoglobin G (IgG) response to model antigens encoded by a recombinant suicide vector based on the Semliki Forest Virus (rSFV) unlike wild-type mice

decreased IgG level ( J:185495 )

• response in response to recombinant Semliki Forest virus (SFV) encoded antigen

hematopoietic system

abnormal class switch recombination ( J:185495 )

• mice exhibit reduced class-switch antibody response in response to recombinant Semliki Forest virus (SFV) encoded antigen compared with control mice

decreased T cell number ( J:185495 )

• severe T cell deficiency

absent CD4-positive, alpha-beta T cells ( J:167119 )

absent CD8-positive, alpha-beta T cells ( J:167119 )

decreased IgG level ( J:185495 )

• response in response to recombinant Semliki Forest virus (SFV) encoded antigen