Phenotypes Associated with This Genotype

Genotype
MGI:4867201

• Allelic Composition: Kcna2^Pgu/Kcna2⁺
• Genetic Background: involves: C3H/HeJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Postnatal growth retardation in Kcna2^Pgu/Kcna2⁺ and Kcna2^Pgu/Kcna2^Pgu mice

behavior/neurological

limb grasping ( J:166795 )

• in some mice

tremors ( J:166795 )

• severe on a balance beam

ataxia ( J:166795 )

• on a balance beam

impaired coordination ( J:166795 )

• on a rotarod and balance beam

• however, treatment with acetazolamide or transgene complementation improves rotarod performance

decreased grip strength ( J:166795 )

abnormal posture ( J:166795 )

• flattened on a balance beam

abnormal gait ( J:166795 )

• beginning at P7, some mice exhibit abnormal gait with higher stance and splayed hind limbs unlike wild-type mice

• gait abnormality is more severe at P10

• some mice exhibit increased stride length and width and increased toe spread compared with wild-type mice

long stride length ( J:166795 )

nervous system

impaired ability to fire action potentials ( J:166795 )

• the frequency of Purkinje cell action potential firing is reduced compared to in wild-type mice

• however, basket cell firing rate is normal

abnormal single cell response ( J:166795 )

• Purkinje cells spiking frequency is reduced compared to in wild-type mice

abnormal inhibitory postsynaptic currents ( J:166795 )

• mice exhibit increased spontaneous GABAergic inhibitory postsynaptic currents compared with wild-type mice

abnormal miniature inhibitory postsynaptic currents ( J:166795 )

• mice exhibit larger miniature inhibitory postsynaptic currents compared with wild-type mice

growth/size/body

decreased body size ( J:166795 )

• beginning at P7 in some mice

decreased body weight ( J:166795 )

• beginning at P7 in some mice