Phenotypes Associated with This Genotype

Genotype
MGI:4867007

• Allelic Composition: Jag1^tm1Grid/Jag1^tm2Grid; Tg(Tagln-cre)1Her/0
• Genetic Background: involves: 129S1/Sv * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:166769 )

• no mutants survive past P2

perinatal lethality, incomplete penetrance ( J:166769 )

• 50% of mutants die by P1

cardiovascular system

retroesophageal right subclavian artery ( J:166769 )

• seen in some mutants

patent ductus arteriosus ( J:166769 )

• 95% of mutants exhibit patent ductus arteriosus

abnormal vascular smooth muscle morphology ( J:166769 )

• defects in vascular smooth muscle cell differentiation in the outer layers of the medial wall of the ductus arteriosus and descending aorta at E17.5 when the ductus arteriosus is still patent, however the ascending limb of the aorta and the pulmonary artery trunk have normal vascular smooth muscle cell differentiation

homeostasis/metabolism

cyanosis ( J:166769 )

muscle

abnormal vascular smooth muscle morphology ( J:166769 )

• defects in vascular smooth muscle cell differentiation in the outer layers of the medial wall of the ductus arteriosus and descending aorta at E17.5 when the ductus arteriosus is still patent, however the ascending limb of the aorta and the pulmonary artery trunk have normal vascular smooth muscle cell differentiation

cellular

patent ductus arteriosus ( J:166769 )

• 95% of mutants exhibit patent ductus arteriosus