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Phenotypes Associated with This Genotype
Genotype
MGI:4850095
Allelic
Composition		 Pik3cdtm2.1Tnr/Pik3cdtm2.1Tnr
Tnfrsf4tm2(cre)Nik/Tnfrsf4+
Genetic
Background		 involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pik3cdtm2.1Tnr mutation (0 available); any Pik3cd mutation (44 available)
Tnfrsf4tm2(cre)Nik mutation (1 available); any Tnfrsf4 mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased germinal center B cell number ( J:164283 )
• following immunization
decreased spleen germinal center number ( J:164283 )
• following immunization, the ratio of germinal centers per B cell follicle is reduced compared to in similarly treated wild-type mice
abnormal humoral immune response ( J:164283 )
• following immunization, the number of NP2-binding antibody forming cells in the bone marrow and spleen is reduced compared to in wild-type mice
decreased IgG1 level ( J:164283 )
• following immunization, high-affinity IgG1 antibody titers are modestly reduced compared to in similarly treated wild-type mice

hematopoietic system
decreased germinal center B cell number ( J:164283 )
• following immunization
decreased spleen germinal center number ( J:164283 )
• following immunization, the ratio of germinal centers per B cell follicle is reduced compared to in similarly treated wild-type mice
decreased IgG1 level ( J:164283 )
• following immunization, high-affinity IgG1 antibody titers are modestly reduced compared to in similarly treated wild-type mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/20/2026
MGI 6.24 		The Jackson Laboratory