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Phenotypes Associated with This Genotype
Genotype
MGI:4850046
Allelic
Composition
Fbn2tm1Rmz/Fbn2tm1Rmz
Genetic
Background
involves: 129S/SvEv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fbn2tm1Rmz mutation (0 available); any Fbn2 mutation (53 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Experimental osteolysis occurs more extensively in Fbn1tm3Rmz/Fbn1tm3Rmz mice

skeleton
• mutants exhibit 27% less bone mass by 3 months of age
• mutants exhibit a 55% reduction in bone formation rate by 3 months of age
• mutants show greater than normal osteolytic response to locally implanted lipopolysaccharide-coated titanium particles
• isolated mutant preosteoclasts cultured with mutant osteoblasts exhibit augmented differentation and activity, indicating greater osteoclastogenic potential of osteoblasts

Mouse Models of Human Disease
OMIM ID Ref(s)
Arthrogryposis, Distal, Type 9; DA9 121050 J:166786


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory