Mouse Genome Informatics
hm
    Fbn2tm1Rmz/Fbn2tm1Rmz
involves: 129S/SvEv
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       

Experimental osteolysis occurs more extensively in Fbn1tm3Rmz/Fbn1tm3Rmz mice

skeleton
• mutants exhibit 27% less bone mass by 3 months of age
• mutants exhibit a 55% reduction in bone formation rate by 3 months of age
• mutants show greater than normal osteolytic response to locally implanted lipopolysaccharide-coated titanium particles
• isolated mutant preosteoclasts cultured with mutant osteoblasts exhibit augmented differentation and activity, indicating greater osteoclastogenic potential of osteoblasts

Mouse Models of Human Disease
OMIM IDRef(s)
Arthrogryposis, Distal, Type 9; DA9 121050 J:166786