Mouse Genome Informatics
tg
    Tg(Prnp-SOD1*G37R,-PSEN1)110Dbo/Tg(Prnp-SOD1*G37R,-PSEN1)110Dbo
involves: C3H * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
nervous system
• by 7 to 9 months, mice develop motor neuron disease that progresses rapidly unlike wild-type mice

behavior/neurological
• within 1 to 3 weeks of visible gait disturbance

Mouse Models of Human Disease
OMIM IDRef(s)
Amyotrophic Lateral Sclerosis 1; ALS1 105400 J:104655