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Phenotypes Associated with This Genotype
Genotype
MGI:4849842
Allelic
Composition
Tg(Prnp-SOD1*G37R,-PSEN1)110Dbo/Tg(Prnp-SOD1*G37R,-PSEN1)110Dbo
Genetic
Background
involves: C3H * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• by 7 to 9 months, mice develop motor neuron disease that progresses rapidly unlike wild-type mice

behavior/neurological
• within 1 to 3 weeks of visible gait disturbance

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
amyotrophic lateral sclerosis type 1 DOID:0060193 OMIM:105400
J:104655


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/10/2017
MGI 6.10
The Jackson Laboratory