Phenotypes Associated with This Genotype

Genotype
MGI:4849640

• Allelic Composition: Cops5^tm1Fxc/Cops5^tm1Fxc
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:166561 )

• mice die between E6.5 and E7.5

embryo

abnormal inner cell mass apoptosis ( J:166561 )

• increased apoptosis in inner cell mass cultures

increased embryonic tissue cell apoptosis ( J:166561 )

• in embryos at E6.5

decreased inner cell mass proliferation ( J:166561 )

• cultured inner cell mass exhibit reduced proliferation compared with wild-type cells

embryonic growth retardation ( J:166561 )

• at E6.5

decreased embryo size ( J:166561 )

• at E6.5

abnormal egg cylinder morphology ( J:166561 )

• mouse embryonic fibroblasts exhibit spontaneous DNA break compared with wild-type cells

cellular

abnormal inner cell mass apoptosis ( J:166561 )

• increased apoptosis in inner cell mass cultures

increased embryonic tissue cell apoptosis ( J:166561 )

• in embryos at E6.5

decreased inner cell mass proliferation ( J:166561 )

• cultured inner cell mass exhibit reduced proliferation compared with wild-type cells

abnormal DNA repair ( J:166561 )

• impaired in mouse embryonic fibroblasts

spontaneous chromosome breakage ( J:166561 )

• mouse embryonic fibroblasts exhibit spontaneous DNA break compared with wild-type cells

growth/size/body

embryonic growth retardation ( J:166561 )

• at E6.5

decreased embryo size ( J:166561 )

• at E6.5

homeostasis/metabolism

abnormal DNA repair ( J:166561 )

• impaired in mouse embryonic fibroblasts