Phenotypes for Adam22 Lgi4 MGI:4849631 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Adam22^tm1Sag/Adam22^tm1Sag Lgi4^tm1Sjm/Lgi4^tm1Sjm
Genetic Background	involves: C57BL/6 * CBA * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adam22^tm1Sag mutation (2 available); any Adam22 mutation (72 available)
Lgi4^tm1Sjm mutation (0 available); any Lgi4 mutation (32 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, incomplete penetrance ( J:166449 )

• most mice die immediately after birth

nervous system

abnormal glial cell morphology ( J:166449 )

• fewer glial cells form from cultured gut neural crest stem cells compared to when wild-type cells are used

• enteric sections exhibit fewer glial cells than in wild-type mice

demyelination ( J:166449 )

• of peripheral nerves

growth/size/body

decreased body size ( J:166449 )

decreased body weight ( J:166449 )

• at P1 and P12

postnatal growth retardation ( J:166449 )

limbs/digits/tail

abnormal forelimb morphology ( J:166449 )

• arthrogryposis-like paw

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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