Phenotypes Associated with This Genotype

Genotype
MGI:4849515

• Allelic Composition: Magel2^tm1.1Mus/Magel2⁺
• Genetic Background: B6.129S2-Magel2^tm1.1Mus

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, incomplete penetrance ( J:166548 )

• when this allele is inherited paternally, half of expected mice survive to P1

• however, lethality can be rescued by injection of oxytocin

behavior/neurological

absent gastric milk in neonates ( J:166548 )

• when this allele is inherited paternally

abnormal suckling behavior ( J:166548 )

• when this allele is inherited paternally, more mice exhibit weak suckling activity compared with wild-type mice

• however, suckling activity can be rescued by injection of oxytocin

nervous system

nervous system phenotype ( J:166548 )

N • brain morphology is normal

abnormal hypothalamus secretion ( J:166548 )

• when this allele is inherited paternally, hypothalamic levels of amidated neuropeptides (oxytocin, arginine-vasopressin, and orexin-A) compared with wild-type mice

• when this allele is inherited paternally, maturation of oxytocin in the hypothalamus is impaired and intermediate forms accumulate compared to in wild-type mice

• however, mice exhibit normal hypothalamic levels of adrenocorticotropic hormone and alpha-melanocyte-stimulating hormone and pituitary levels of oxytocin, arginine-vasopressin, and orexin-A

homeostasis/metabolism

decreased circulating glucose level ( J:166548 )

• 12 hours after birth when this allele is inherited paternally

growth/size/body

decreased body weight ( J:166548 )

• between P0 and P3 when this allele is inherited paternally

• however, weight between P3 and P4 is normal and only tends to be lower until weaning