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Phenotypes Associated with This Genotype
Genotype
MGI:4848186
Allelic
Composition
Gjb6tm1.1Fama/Gjb6tm1.1Fama
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gjb6tm1.1Fama mutation (1 available); any Gjb6 mutation (7 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hearing/vestibular/ear
• cochlear non-sensory cells exhibit reduced frequency of occurrence and peak amplitude of calcium ion transits compared with wild-type cells
• medium to large amplitude events are missing unlike in wild-type mice
• however, mice exhibit normal endocochlear potential

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
autosomal recessive nonsyndromic deafness 1A DOID:0110475 OMIM:220290
J:166362


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/08/2017
MGI 6.10
The Jackson Laboratory