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Phenotypes Associated with This Genotype
Genotype
MGI:4848133
Allelic
Composition		 Ptentm1Rps/Pten+
RictorGt(RRR347)Byg/Rictor+
Genetic
Background		 involves: 129P2/OlaHsd * 129S1/Sv * BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptentm1Rps mutation (1 available); any Pten mutation (87 available)
RictorGt(RRR347)Byg mutation (0 available); any Rictor mutation (141 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
extended life span ( J:144810 )
• double mutants tend to live longer than single heterozygous Pten mice

endocrine/exocrine glands
prostate gland hyperplasia ( J:144810 )
• prostates exhibit signs of hyperplasia but lesions are less severe than in single heterozygous Pten mice

reproductive system
prostate gland hyperplasia ( J:144810 )
• prostates exhibit signs of hyperplasia but lesions are less severe than in single heterozygous Pten mice

neoplasm
decreased tumor incidence ( J:144810 )
• mutants are protected from prostate cancer development: only 1 of 10 double mutants developed a tumor compared to 5 of 9 single heterozygous Pten mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory