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Phenotypes Associated with This Genotype
Genotype
MGI:4847596
Allelic
Composition		 \Aplp2tm1Dbo/\Aplp2tm1Dbo
\Apptm1Dbo/\Apptm3.1Zhe
Genetic
Background		 involves: 129/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aplp2tm1Dbo mutation (1 available); any Aplp2 mutation (30 available)
Apptm1Dbo mutation (4 available); any App mutation (111 available)
Apptm3.1Zhe mutation (0 available); any App mutation (111 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, incomplete penetrance ( J:166379 )
• although born in Mendelian ratios, few mice survive to adulthood

nervous system
abnormal neuromuscular synapse morphology ( J:166379 )
• neuromuscular junction exhibit mislocalization of choline transporters and reduced synaptophysin staining compared with wild-type mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory