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Phenotypes Associated with This Genotype
Genotype
MGI:4845867
Allelic
Composition		 Pik3catm1.1Rzl/Pik3catm1.1Rzl
A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic
Background		 involves: 129S4/SvJaeSor * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A1cfTg(Myh6-cre/Esr1*)1Jmk mutation (5 available); any A1cf mutation (37 available)
Pik3catm1.1Rzl mutation (0 available); any Pik3ca mutation (65 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
decreased heart weight ( J:166421 )
• in tamoxifen-treated mice
increased heart left ventricle size ( J:166421 )
• mildly in tamoxifen-treated mice
thick ventricular wall ( J:166421 )
• posterior wall thickness in tamoxifen-treated mice is slightly decreased compared to in wild-type mice
decreased cardiac muscle contractility ( J:166421 )
• in tamoxifen-treated mice
abnormal myocardial fiber physiology ( J:166421 )
• myocytes of tamoxifen-treated mice exhibit reduced inward calcium ion current density compared with wild-type cells

muscle
decreased cardiac muscle contractility ( J:166421 )
• in tamoxifen-treated mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory