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Phenotypes Associated with This Genotype
Genotype
MGI:4844011
Allelic
Composition		 Hand1tm2.1(Hand1)Abfi/Hand1tm2.1(Hand1)Abfi
Hand2tm1Dsr/Hand2tm1Dsr
Genetic
Background		 involves: 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hand1tm2.1(Hand1)Abfi mutation (0 available); any Hand1 mutation (14 available)
Hand2tm1Dsr mutation (0 available); any Hand2 mutation (13 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal cardiovascular system morphology ( J:164028 )
• cardiac morphogenesis is comparable to both single mutants
thin ventricular wall ( J:164028 )
• myocardium shows a thin ventricular wall

embryo
abnormal rostral-caudal axis patterning ( J:164028 )
• exhibit poor caudal development compared to either single mutant

growth/size/body
decreased embryo size ( J:164028 )

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory