Phenotypes Associated with This Genotype

Genotype
MGI:4844009

• Allelic Composition: Hand1^{tm2.1(Hand1)Abfi}/Hand1^{tm2.1(Hand1)Abfi}
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, incomplete penetrance ( J:164028 )

• majority of embryos are viable to E10.5, with 8% viable to E12.5

cardiovascular system

abnormal cardiovascular system morphology ( J:164028 )

• mice exhibit similar phenotypes to Hand1^{tm1(Hand1)Abfi} but at a less severe penetrance

abnormal cardiac outflow tract development ( J:164028 )

• reduced outflow tract cushions at E12.5

abnormal interventricular septum morphology ( J:164028 )

• septal cardiomyocytes are disorganized in the forming interventricular septum at E12.5

thin ventricular wall ( J:164028 )

• decrease in ventricular wall thickness at E12

hemopericardium ( J:164028 )

• pericardial hemorrhaging at E12.5

craniofacial

abnormal craniofacial morphology ( J:164028 )

• craniofacial defects at E12.5

embryo

abnormal embryo development ( J:164028 )

• mice exhibit similar phenotypes to Hand1^{tm1(Hand1)Abfi} but at a less severe penetrance

abnormal embryo turning ( J:164028 )

• embryo turning is impaired

abnormal rostral-caudal axis patterning ( J:164028 )

• severe caudal defects at E12.5

decreased embryo size ( J:164028 )

• embryos surviving to E12.5 are slightly smaller than wild-type

abnormal limb bud morphology ( J:164028 )

• hypoplastic limb buds at E12.5

growth/size/body

decreased embryo size ( J:164028 )

• embryos surviving to E12.5 are slightly smaller than wild-type

homeostasis/metabolism

hemopericardium ( J:164028 )

• pericardial hemorrhaging at E12.5

cellular

decreased cell proliferation ( J:164028 )

• decrease in the rate of global cell proliferation at E9.5

limbs/digits/tail

abnormal limb bud morphology ( J:164028 )

• hypoplastic limb buds at E12.5