Phenotypes Associated with This Genotype

Genotype
MGI:4844007

• Allelic Composition: Hand1^{tm2(Hand1)Abfi}/Hand1^{tm2(Hand1)Abfi}
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:164028 )

• no viable homozygotes are observed after E10.5

cardiovascular system

abnormal cardiac outflow tract development ( J:164028 )

• at E9.5, the mesenchymal cells are largely absent from the forming outflow tract cushions

abnormal heart morphology ( J:164028 )

• heart is thinner and dilated at E9.5

abnormal myocardial trabeculae morphology ( J:164028 )

• hearts are hypotrabeculated at E9.5

abnormal heart septum morphology ( J:164028 )

• a forming aortico-pulmonary (AP) septum is not visible at E9.5

enlarged heart ( J:164028 )

• hearts appear large at E9.5 compared with overall embryo size

dilated heart ( J:164028 )

• heart is thinner and dilated at E9.5

embryo

abnormal mesoderm development ( J:164028 )

• pharyngeal mesoderm proximal to the outflow tract is reduced at E9.5

abnormal neural tube morphology ( J:164028 )

• crooked neural tube in the caudal region

enlarged allantois ( J:164028 )

abnormal visceral yolk sac morphology ( J:164028 )

• yolk sac blistering due to separation of the visceral mesoderm and endoderm of the yolk sac

impaired placental function ( J:164028 )

• placental insufficiency

nervous system

abnormal neural tube morphology ( J:164028 )

• crooked neural tube in the caudal region

cellular

decreased cell proliferation ( J:164028 )

• decrease in the rate of global cell proliferation at E9.5

muscle

abnormal myocardial trabeculae morphology ( J:164028 )

• hearts are hypotrabeculated at E9.5

growth/size/body

enlarged heart ( J:164028 )

• hearts appear large at E9.5 compared with overall embryo size