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Phenotypes Associated with This Genotype
Genotype
MGI:4843917
Allelic
Composition
Nrp2tm1.2Mom/Nrp2tm1.2Mom
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * FVB/NJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nrp2tm1.2Mom mutation (1 available); any Nrp2 mutation (50 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• all mutants treated with KA to induce seizures die within a week
• some mice die in spontaneous status epilepticus between P7 and P21

behavior/neurological
• all mutants treated with kainic acid (KA) to induce seizures die within a week
• 12 of 51 mice exhibit random handling-induced seizures
• 12 of 51 mice exhibit random handling-induced seizures

muscle
• 12 of 51 mice exhibit random handling-induced seizures

nervous system
• all mutants treated with kainic acid (KA) to induce seizures die within a week
• 12 of 51 mice exhibit random handling-induced seizures
• 12 of 51 mice exhibit random handling-induced seizures
• mutants exhibit selective loss of GABAergic cells in the hippocampus
• Parv+ and NPY+ neurons are reduced in the hippocampus

Mouse Models of Human Disease
OMIM ID Ref(s)
Autism 209850 J:166116


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory