Mouse Genome Informatics
hm
    Nrp2tm1.2Mom/Nrp2tm1.2Mom
involves: 129P2/OlaHsd * C57BL/6 * FVB/NJ
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging
• all mutants treated with KA to induce seizures die within a week
• some mice die in spontaneous status epilepticus between P7 and P21

behavior/neurological
• all mutants treated with kainic acid (KA) to induce seizures die within a week
• 12 of 51 mice exhibit random handling-induced seizures
• 12 of 51 mice exhibit random handling-induced seizures

muscle
• 12 of 51 mice exhibit random handling-induced seizures

nervous system
• all mutants treated with kainic acid (KA) to induce seizures die within a week
• 12 of 51 mice exhibit random handling-induced seizures
• 12 of 51 mice exhibit random handling-induced seizures
• mutants exhibit selective loss of GABAergic cells in the hippocampus
• Parv+ and NPY+ neurons are reduced in the hippocampus

Mouse Models of Human Disease
OMIM IDRef(s)
Autism 209850 J:166116