Phenotypes Associated with This Genotype

Genotype
MGI:4843435

• Allelic Composition: Il2^tm1Hor/Il2^tm1Hor
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased T-helper 17 cell number ( J:120176 )

• increase in the percentage of IL-17-producing cells in culturing CD4+ T cells in vitro under Th17-polarizing conditions

• greater proportion of IL-17-positive cells (most of which CD4 positive) in peripheral lymph nodes

• 30-fold difference in absolute numbers of mesenteric Th17 cells compared with wild-type mice

increased circulating interleukin-17 level ( J:120176 )

• elevated serum IL-17 concentration at 3 months old

homeostasis/metabolism

increased circulating interleukin-17 level ( J:120176 )

• elevated serum IL-17 concentration at 3 months old

hematopoietic system

increased T-helper 17 cell number ( J:120176 )

• increase in the percentage of IL-17-producing cells in culturing CD4+ T cells in vitro under Th17-polarizing conditions

• greater proportion of IL-17-positive cells (most of which CD4 positive) in peripheral lymph nodes

• 30-fold difference in absolute numbers of mesenteric Th17 cells compared with wild-type mice