Phenotypes Associated with This Genotype

Genotype
MGI:4843396

• Allelic Composition: Prkcq^tm1Litt/Prkcq^tm1Litt
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal glucose homeostasis ( J:92834 )

• lipid infusion does not alter insulin sensitivity, muscular and brown fat adipose tissue glucose uptake, or whole-body and muscular metabolic flux, including glycolysis and glycogen synthesis, unlike in similarly treated wild-type mice

increased insulin sensitivity ( J:92834 )

• lipid infused mice do not exhibit a decrease in insulin sensitivity compared with similarly treated wild-type mice

immune system

immune system phenotype ( J:141128 )

N • mice exhibit normal regulatory T cells-mediated inhibition of T cell activation, IL2-induced expansion of regulatory T cells, and regulatory T cells TGF-beta production

increased T cell apoptosis ( J:141128 )

• following CD3 and CD28 stimulation, T cell apoptosis is accelerated compared to in similarly treated wild-type cells

decreased T cell proliferation ( J:186080 )

• when stimulated by anti-CD3 antibodies or antigens (in vitro and in vivo)

decreased DN1 thymic pro-T cell number ( J:186080 )

abnormal positive T cell selection ( J:186080 )

• mildly impaired

abnormal effector T cell morphology ( J:186080 )

• the ratio of CD4 to CD8 T cells is lower than in wild-type mice

decreased CD4-positive, alpha-beta T cell number ( J:186080 )

decreased CD8-positive, alpha-beta T cell number ( J:186080 )

decreased NK T cell number ( J:141128 )

adipose tissue

abnormal adipocyte glucose uptake ( J:92834 )

• lipid infusion does not alter brown adipose tissue glucose uptake unlike in wild-type mice

• however, white adipose tissue glucose uptake is similarly decreased following lipid infusion as in wild-type mice

muscle

abnormal muscle cell glucose uptake ( J:92834 )

• lipid infusion does not alter muscle glucose uptake unlike in wild-type mice

hematopoietic system

increased T cell apoptosis ( J:141128 )

• following CD3 and CD28 stimulation, T cell apoptosis is accelerated compared to in similarly treated wild-type cells

decreased T cell proliferation ( J:186080 )

• when stimulated by anti-CD3 antibodies or antigens (in vitro and in vivo)

decreased DN1 thymic pro-T cell number ( J:186080 )

abnormal positive T cell selection ( J:186080 )

• mildly impaired

abnormal effector T cell morphology ( J:186080 )

• the ratio of CD4 to CD8 T cells is lower than in wild-type mice

decreased CD4-positive, alpha-beta T cell number ( J:186080 )

decreased CD8-positive, alpha-beta T cell number ( J:186080 )

decreased NK T cell number ( J:141128 )

cellular

abnormal adipocyte glucose uptake ( J:92834 )

• lipid infusion does not alter brown adipose tissue glucose uptake unlike in wild-type mice

• however, white adipose tissue glucose uptake is similarly decreased following lipid infusion as in wild-type mice

increased T cell apoptosis ( J:141128 )

• following CD3 and CD28 stimulation, T cell apoptosis is accelerated compared to in similarly treated wild-type cells

decreased T cell proliferation ( J:186080 )

• when stimulated by anti-CD3 antibodies or antigens (in vitro and in vivo)

abnormal muscle cell glucose uptake ( J:92834 )

• lipid infusion does not alter muscle glucose uptake unlike in wild-type mice

endocrine/exocrine glands

decreased DN1 thymic pro-T cell number ( J:186080 )