Phenotypes Associated with This Genotype

Genotype
MGI:4843170

• Allelic Composition: Pkd1^tm1Ggg/Pkd1^tm2Ggg; Meox2^tm1(cre)Sor/Meox2⁺
• Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:165114 )

• mice that are born alive die shortly after birth

lethality throughout fetal growth and development, incomplete penetrance ( J:165114 )

• fewer than expected mice survive to birth but more than in Pkd1^tm1Ggg homozygotes

embryo

abnormal placenta morphology ( J:165114 )

• placental abnormalities observed in Pkd1^tm1Ggg homozygotes are partially rescued

abnormal placenta vasculature ( J:165114 )

• some mice exhibit fewer fetal vessels and more dilated vascular spaces in the placenta compared with wild-type mice

• on average, fetal vessel density in the placenta is decreased compared to in wild-type mice

homeostasis/metabolism

edema ( J:165114 )

polyhydramnios ( J:165114 )

renal/urinary system

kidney cyst ( J:165114 )

respiratory system

respiratory failure ( J:165114 )

cardiovascular system

cardiovascular system phenotype ( J:165114 )

N • edematous mice exhibit normal heart morphology

abnormal placenta vasculature ( J:165114 )

• some mice exhibit fewer fetal vessels and more dilated vascular spaces in the placenta compared with wild-type mice

• on average, fetal vessel density in the placenta is decreased compared to in wild-type mice

growth/size/body

kidney cyst ( J:165114 )