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Phenotypes Associated with This Genotype
Genotype
MGI:4840407
Allelic
Composition		 Sh2d1atm1Cpt/Sh2d1atm1Cpt
Sh2d1b1/Sh2d1b2tm1.1Cpt/Sh2d1b1/Sh2d1b2tm1.1Cpt
Genetic
Background		 involves: 129S4/SvJae * BALB/cJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sh2d1atm1Cpt mutation (0 available); any Sh2d1a mutation (9 available)
Sh2d1b1/Sh2d1b2tm1.1Cpt mutation (0 available); any Sh2d1b1 mutation (9 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
impaired natural killer cell mediated cytotoxicity ( J:166054 )
• in vivo clearance of RMAS/CD48+ or P815/CD48+ tumors cells is impaired compared to in wild-type mice

hematopoietic system
impaired natural killer cell mediated cytotoxicity ( J:166054 )
• in vivo clearance of RMAS/CD48+ or P815/CD48+ tumors cells is impaired compared to in wild-type mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory