Phenotypes Associated with This Genotype

Genotype
MGI:4840315

• Allelic Composition: Mcl1^tm1Dmta/Mcl1^tm1Dmta; Tg(Aicda-cre)9Mbu/0
• Genetic Background: B6.Cg-Mcl1^tm1Dmta Tg(Aicda-cre)9Mbu

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:166069 )

N • affinity maturation among NP-reactive B cells is normal

absent germinal center B cells ( J:166069 )

• following immunization with NP-KLH

absent memory B cells ( J:166069 )

• following immunization with NP-KLH

decreased IgG1 level ( J:166069 )

• following immunization with NP-KLH, the frequency of NP-specific IgG1 in the serum, spleen and bone marrow compared to in similarly treated wild-type mice

hematopoietic system

absent germinal center B cells ( J:166069 )

• following immunization with NP-KLH

absent memory B cells ( J:166069 )

• following immunization with NP-KLH

decreased IgG1 level ( J:166069 )

• following immunization with NP-KLH, the frequency of NP-specific IgG1 in the serum, spleen and bone marrow compared to in similarly treated wild-type mice