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Phenotypes Associated with This Genotype
Genotype
MGI:4840315
Allelic
Composition		 Mcl1tm1Dmta/Mcl1tm1Dmta
Tg(Aicda-cre)9Mbu/0
Genetic
Background		 B6.Cg-Mcl1tm1Dmta Tg(Aicda-cre)9Mbu
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mcl1tm1Dmta mutation (0 available); any Mcl1 mutation (35 available)
Tg(Aicda-cre)9Mbu mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:166069 )
N
• affinity maturation among NP-reactive B cells is normal
absent germinal center B cells ( J:166069 )
• following immunization with NP-KLH
absent memory B cells ( J:166069 )
• following immunization with NP-KLH
decreased IgG1 level ( J:166069 )
• following immunization with NP-KLH, the frequency of NP-specific IgG1 in the serum, spleen and bone marrow compared to in similarly treated wild-type mice

hematopoietic system
absent germinal center B cells ( J:166069 )
• following immunization with NP-KLH
absent memory B cells ( J:166069 )
• following immunization with NP-KLH
decreased IgG1 level ( J:166069 )
• following immunization with NP-KLH, the frequency of NP-specific IgG1 in the serum, spleen and bone marrow compared to in similarly treated wild-type mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory