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Phenotypes Associated with This Genotype
Genotype
MGI:4840269
Allelic
Composition		 Adgra2tm1Cjku/Adgra2tm2Cjku
Tg(Pdgfb-icre/ERT2,-EGFP)1Frut/0
Genetic
Background		 involves: 129/Sv * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adgra2tm1Cjku mutation (0 available); any Adgra2 mutation (43 available)
Adgra2tm2Cjku mutation (0 available); any Adgra2 mutation (43 available)
Tg(Pdgfb-icre/ERT2,-EGFP)1Frut mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal blood vessel morphology ( J:166127 )
• basally localized glomeruloid malformations in hemorrhagic areas of the CNS
abnormal vascular branching morphogenesis ( J:166127 )
• central nervous system (CNS) angiogenic arrest
internal hemorrhage ( J:166127 )
• stated to fully recapitulate the phenotype seen in mice homozygous for Gpr124tm1Cjku
• forebrain hemorrhage

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory