Phenotypes Associated with This Genotype

Genotype
MGI:4840267

• Allelic Composition: Adgra2^tm1Cjku/Adgra2^tm1Cjku
• Genetic Background: involves: 129

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:166127 )

• from E15.5 onwards; no embryos are recovered at E17.5

cardiovascular system

abnormal blood vessel morphology ( J:166127 )

• numerous packed endothelial cells with scant cytoplasm enveloped by pericytes are seen in CNS vascular malformations

abnormal angiogenesis ( J:166127 )

• CNS specific vascular patterning defects

abnormal vascular branching morphogenesis ( J:166127 )

• decrease in angiogenic sprouting into the forebrain telencephalon and thickening of the underlying perineural vascular plexus resulting in a nearly avascular telencephalon

• by E14.5 defects in sprouting result in basally localized glomeruloid malformations and a distally avascular telencephalon

• filopodial extensions are reduced or absent in endothelial cells in the glomeruloid malformations and when present extend laterally rather than towards the ventricles

• however, sprouting is not affected in the embryonic diencephalon, mid- and hindbrain, or in nonneural tissues

abnormal perineural vascular plexus morphology ( J:166127 )

• decrease in angiogenic sprouting into the forebrain telencephalon and thickening of the underlying perineural vascular plexus resulting in a nearly avascular telencephalon

internal hemorrhage ( J:166127 )

• beginning at E11.5 embryos display progressive central nervous system (CNS) hemorrhage originating in forebrain telencephalon and ventral neural tube

• by E14.5 hemorrhagic glomeruloid malformations are seen in the telencephalon, ventral neural tube and forebrain ganglionic eminences

nervous system

abnormal neural tube morphology ( J:166127 )

• by E14.5 hemorrhagic glomeruloid malformations are seen in the ventral neural tube

abnormal telencephalon morphology ( J:166127 )

• decrease in angiogenic sprouting into the forebrain telencephalon and thickening of the underlying perineural vascular plexus resulting in a nearly avascular telencephalon

• by E14.5 defects in sprouting result in basally localized glomeruloid malformations and a distally avascular telencephalon

abnormal embryonic/fetal subventricular zone morphology ( J:166127 )

• by E14.5 hemorrhagic glomeruloid malformations are seen in the forebrain ganglionic eminences

abnormal nervous system physiology ( J:166127 )

• beginning at E11.5 embryos display progressive central nervous system (CNS) hemorrhage originating in forebrain telencephalon and ventral neural tube

embryo

abnormal neural tube morphology ( J:166127 )

• by E14.5 hemorrhagic glomeruloid malformations are seen in the ventral neural tube