Phenotypes Associated with This Genotype

Genotype
MGI:4840234

• Allelic Composition: Brk1^{Gt(DC0002)Wtsi}/Brk1^{Gt(DC0002)Wtsi}
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality before implantation, complete penetrance ( J:166082 )

embryo

failure of blastocyst to hatch from the zona pellucida ( J:166082 )

• cultured embryos fail to hatch by E4.5 and remain as degenerated blastocysts

embryonic growth retardation ( J:166082 )

• embryos that do implant are underdeveloped

disorganized embryonic tissue ( J:166082 )

• embryos that do implant are underdeveloped with disorganized cells and diffuse actin distribution

abnormal blastocyst morphology ( J:166082 )

• cultured embryos fail to hatch by E4.5 and remain as degenerated blastocysts

cellular

abnormal actin cytoskeleton morphology ( J:166082 )

• embryos show an abnormal actin network with absence of proper actin fibers at the apical and basolateral boundary

growth/size/body

embryonic growth retardation ( J:166082 )

• embryos that do implant are underdeveloped

reproductive system

failure of embryo implantation ( J:166082 )

♀ • most embryos fail to implant