Phenotypes Associated with This Genotype

Genotype
MGI:4840214

• Allelic Composition: Stat5a^tm2Mam/Stat5a^tm2Mam; Stat5b^tm1Mam/Stat5b^tm1Mam; Myf5^tm3(cre)Sor/Myf5⁺
• Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased lean body mass ( J:119237 )

• reduced lean mass at 8 weeks of age

• normal fraction of lean mass to total body weight

decreased body weight ( J:119237 )

• 12% and 20% smaller for female and male mice respectively, at 8 weeks of age

decreased body length ( J:119237 )

• reduced body length at 8 weeks of age

adipose tissue

increased total body fat amount ( J:119237 )

• a trend toward higher total fat mass at 8 weeks of age

homeostasis/metabolism

decreased circulating insulin-like growth factor I level ( J:119237 )

• 15% decrease in circulating IGF-I level at 8 weeks of age

increased circulating triglyceride level ( J:119237 )

• elevated serum triglycerides at 8 weeks of age

impaired glucose tolerance ( J:119237 )

• glucose intolerance in male mice at 30- and 60-min after glucose challenge

• a similar trend in female, but less severe