Phenotypes for Lmna MGI:4840109 MGI Mouse

About Help FAQ

Phenotypes Associated with This Genotype

Allelic Composition	Lmna^tm6Lgf/Lmna^tm6Lgf
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lmna^tm6Lgf mutation (0 available); any Lmna mutation (82 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal cell nucleus morphology ( J:165928 )

• fibroblasts exhibit a higher frequency of nuclei blebs compared with cells from wild-type mice but less than in Lmna^tm7Lgf homozygotes

• nuclear stiffness in fibroblasts is increased compared to cells from wild-type mice and Lmna^tm7Lgf homozygotes

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23