Phenotypes Associated with This Genotype

Genotype
MGI:4840104

• Allelic Composition: Lmna^tm7Lgf/Lmna^tm7Lgf
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Misshapen cell nuclei in embryonic Lmna^tm7Lgf/Lmna^tm7Lgf fibroblasts

mortality/aging

mortality/aging ( J:165928 )

N • mice exhibit normal survival

cellular

abnormal cell nucleus morphology ( J:165928 )

• fibroblasts exhibit a higher frequency of nuclei blebs compared with cells from wild-type mice and Lmna^tm6Lgf homozygotes

• however, nuclear stiffness in fibroblalsts is normal

reproductive system

reproductive system phenotype ( J:165928 )

N • mice are fertile