Phenotypes Associated with This Genotype

Genotype
MGI:4839961

• Allelic Composition: Drd3^tm1Dac/Drd3^tm1Dac
• Genetic Background: involves: 129S4/SvJae

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

decreased alcohol consumption ( J:107932 )

• during chronic ethanol treatment

abnormal behavioral response to addictive substance ( J:103704 )

• mice treated with cocaine exhibit reduced hyperactivity and increased head bobbing compared with similarly treated wild-type mice

enhanced behavioral response to alcohol ( J:107932 )

• after a single injection of ethanol, mice exhibit reduced onset time to sleep and longer sleep time compared with similarly treated wild-type mice

increased behavioral withdrawal response ( J:107932 )

• 3 and 6 hours after discontinuation of ethanol treatment, mice exhibit increased levels of withdrawal scores compared with similarly treated wild-type mice

• however, withdrawal scores at 12 and 18 hours are normal

head bobbing ( J:103704 )

• cocaine-treated mice exhibit increased head bobbing compared with similarly treated wild-type mice

decreased locomotor activity ( J:103704 )

• 5 days after cocaine treatment, mice exhibit less induced locomotion compared with similarly treated wild-type mice