Phenotypes Associated with This Genotype

Genotype
MGI:4839913

• Allelic Composition: Adam17^m1Btlr/Adam17^m1Btlr
• Genetic Background: C57BL/6J-Adam17^m1Btlr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased survivor rate ( J:166602 )

• survival rate of homozygotes (16.07%) is slightly lower than the expected Mendelian ratio (25%)

immune system

increased susceptibility to induced colitis ( J:166602 )

decreased circulating tumor necrosis factor level ( J:166602 )

• LPS-stimulated peritoneal macrophages exhibit increased surface expression of TNF, but decreased quantities of soluble TNF

• PMA-stimulated embryonic fibroblasts secrete less TNF than heterozygous controls

homeostasis/metabolism

decreased circulating tumor necrosis factor level ( J:166602 )

• LPS-stimulated peritoneal macrophages exhibit increased surface expression of TNF, but decreased quantities of soluble TNF

• PMA-stimulated embryonic fibroblasts secrete less TNF than heterozygous controls

decreased transforming growth factor beta level ( J:166602 )

• PMA-stimulated embryonic fibroblasts secrete less TGFalpha than controls

growth/size/body

weight loss ( J:166602 )

• significant weight loss is observed with addition of 1% dextran sodium sulfate (DSS) to water

digestive/alimentary system

increased susceptibility to induced colitis ( J:166602 )

integument

waved hair ( J:166602 )

• wavy coat