Phenotypes Associated with This Genotype

Genotype
MGI:4839739

• Allelic Composition: Terf2ip^tm1.1Blas/Terf2ip^tm1.1Blas
• Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6J * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

cellular phenotype ( J:165984 )

N • mouse embryonic fibroblasts transfected with cre exhibit normal proliferation and cell cycle

abnormal telomere morphology ( J:165984 )

• 70% of mouse embryonic fibroblasts transfected with cre exhibit more than three telomere dysfunction induced foci unlike wild-type cells

decreased telomere length ( J:165984 )

• mouse embryonic fibroblasts transfected with cre exhibit an increase in short telomeres and decreased long telomeres compared with wild-type cells

increased chromosomal stability ( J:165984 )

• mouse embryonic fibroblasts transfected with cre and treated with aphidicolin exhibit increased chromosome breaks and complex aberrations compared with similarly treated wild-type cells