Phenotypes Associated with This Genotype

Genotype
MGI:4838532

• Allelic Composition: Tg(ARR2/Pbsn-FGF8)3Prb/0
• Genetic Background: involves: C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

abnormal prostate gland morphology ( J:78918 )

♂ • stromal hypercellularity in the prostate

prostate gland hyperplasia ( J:78918 , J:106650 )

♂ • mice develop prostatic hyperplasia in the lateral and ventral prostates as early as 2-3 months of age and in other lobes between 6 and 16 months of age (J:78918)

♂ • papillary hyperplasia is seen around 16 months of age in ventral, lateral and dorsal prostates but not in the anterior prostate (J:78918)

♂ (J:106650)

increased prostate intraepithelial neoplasia incidence ( J:78918 , J:106650 )

♂ • dysplasia, or low-grade prostatic intraepithelial neoplasia is detected beginning at 5-7 months of age (J:78918)

♂ • 100% of males exhibit multifocal epithelial hyperplasia during the first 14 months and 35% have areas of low-grade prostatic intraepithelial neoplasia (J:78918)

♂ • by 15-24 months of age, 66% of mice have low-grade prostatic intraepithelial neoplasia and 51% of mice have high-grade prostatic intraepithelial neoplasia (J:78918)

♂ • mutants display prostate hyperplasia and PIN but do not progress to adenocarcinoma (J:106650)

prostate gland inflammation ( J:78918 )

♂ • chronic inflammation is seen in the prostrate starting at 5 months of age, mostly involving T cells

immune system

increased inflammatory response ( J:78918 )

• mild chronic inflammation is seen in the stroma of the ductus deferens, seminal vesicle and epididymis in some males

prostate gland inflammation ( J:78918 )

♂ • chronic inflammation is seen in the prostrate starting at 5 months of age, mostly involving T cells

reproductive system

abnormal prostate gland morphology ( J:78918 )

♂ • stromal hypercellularity in the prostate

prostate gland hyperplasia ( J:78918 , J:106650 )

♂ • mice develop prostatic hyperplasia in the lateral and ventral prostates as early as 2-3 months of age and in other lobes between 6 and 16 months of age (J:78918)

♂ • papillary hyperplasia is seen around 16 months of age in ventral, lateral and dorsal prostates but not in the anterior prostate (J:78918)

♂ (J:106650)

increased prostate intraepithelial neoplasia incidence ( J:78918 , J:106650 )

♂ • dysplasia, or low-grade prostatic intraepithelial neoplasia is detected beginning at 5-7 months of age (J:78918)

♂ • 100% of males exhibit multifocal epithelial hyperplasia during the first 14 months and 35% have areas of low-grade prostatic intraepithelial neoplasia (J:78918)

♂ • by 15-24 months of age, 66% of mice have low-grade prostatic intraepithelial neoplasia and 51% of mice have high-grade prostatic intraepithelial neoplasia (J:78918)

♂ • mutants display prostate hyperplasia and PIN but do not progress to adenocarcinoma (J:106650)

prostate gland inflammation ( J:78918 )

♂ • chronic inflammation is seen in the prostrate starting at 5 months of age, mostly involving T cells

neoplasm

increased prostate intraepithelial neoplasia incidence ( J:78918 , J:106650 )

♂ • dysplasia, or low-grade prostatic intraepithelial neoplasia is detected beginning at 5-7 months of age (J:78918)

♂ • 100% of males exhibit multifocal epithelial hyperplasia during the first 14 months and 35% have areas of low-grade prostatic intraepithelial neoplasia (J:78918)

♂ • by 15-24 months of age, 66% of mice have low-grade prostatic intraepithelial neoplasia and 51% of mice have high-grade prostatic intraepithelial neoplasia (J:78918)

♂ • mutants display prostate hyperplasia and PIN but do not progress to adenocarcinoma (J:106650)