Phenotypes Associated with This Genotype

Genotype
MGI:4838438

• Allelic Composition: Elmo1^tm1.2Ravi/Elmo1^tm1.2Ravi
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

multinucleated giant male germ cells ( J:164662 )

♂

abnormal male germ cell apoptosis ( J:164662 )

♂

abnormal testis morphology ( J:164662 )

♂ • mice exhibit an increase in multinucleated giant cell with abundant vacuolar spaces compared to in wild-type mice

abnormal seminiferous tubule morphology ( J:164662 )

♂ • the number of seminiferous tubules containing cell corpses is increased compared to in wild-type mice

abnormal seminiferous tubule epithelium morphology ( J:164662 )

♂

abnormal Sertoli cell morphology ( J:164662 )

♂ • fewer Sertoli cells contain internalization of apoptotic germ cells than in wild-type mice

♂ • however, the number of Sertoli cells is normal

decreased Sertoli cell phagocytosis ( J:164662 )

♂ • Sertoli cells exhibit impaired engulfment of negatively charged 2.1 um carboxylate-modified beads and germ cells compared with wild-type mice

endocrine/exocrine glands

abnormal testis morphology ( J:164662 )

♂ • mice exhibit an increase in multinucleated giant cell with abundant vacuolar spaces compared to in wild-type mice

abnormal seminiferous tubule morphology ( J:164662 )

♂ • the number of seminiferous tubules containing cell corpses is increased compared to in wild-type mice

abnormal seminiferous tubule epithelium morphology ( J:164662 )

♂

abnormal Sertoli cell morphology ( J:164662 )

♂ • fewer Sertoli cells contain internalization of apoptotic germ cells than in wild-type mice

♂ • however, the number of Sertoli cells is normal

cellular

multinucleated giant male germ cells ( J:164662 )

♂

abnormal male germ cell apoptosis ( J:164662 )

♂