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Phenotypes Associated with This Genotype
Genotype
MGI:4838329
Allelic
Composition
Cd226tm1Shib/Cd226tm1Shib
Genetic
Background
involves: BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd226tm1Shib mutation (0 available); any Cd226 mutation (32 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice transplanted with Meth A tumor cells or treated with 25 ug 3-methylcholantrene (MCA) exhibit increased mortality compared with similarly treated wild-type mice

immune system
• mice clear fewer RMA-S-CD155 to RMA-S cells than in similarly treated wild-type mice
• NK fail to exhibit cytolysis towards Yac-1 tumor cells unlike wild-type cells
• NK cells exhibit less cytotoxicity towards RMA-S-CD155 compared with wild-type cells
• towards RMA-CD155 and EL-4 cells

neoplasm
• all mice transplanted with Meth A cells develop tumors by day 20 compared with 6 of 10 similarly treated wild-type mice
• mice treated with 25 ug 3-methylcholantrene (MCA) exhibit increased fibrosarcoma compared with similarly treated wild-type mice
• mice exhibit 7,12-dimethylbenz[a]anthracene (DMBA)-induced papilloma compared with similarly treated wild-type mice

homeostasis/metabolism
• mice treated with 25 ug 3-methylcholantrene (MCA) exhibit increased fibrosarcoma compared with similarly treated wild-type mice
• mice exhibit 7,12-dimethylbenz[a]anthracene (DMBA)-induced papilloma compared with similarly treated wild-type mice

hematopoietic system
• NK fail to exhibit cytolysis towards Yac-1 tumor cells unlike wild-type cells
• NK cells exhibit less cytotoxicity towards RMA-S-CD155 compared with wild-type cells
• towards RMA-CD155 and EL-4 cells


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/25/2025
MGI 6.24
The Jackson Laboratory