mortality/aging
• increased mortality following acute infection with Schistosoma mansoni compared to wild-type mice
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immune system
• marked distension and inflammation of the ileum in S. mansoni infected mice
• circulating levels of LPS in S. mansoni infected mice are elevated indicating impaired integrity of the gut
• T cells in the intestine have a Th1 like phenotype in S. mansoni infected mice rather than the Th2 like phenotype seen in wild-type mice
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• in an anti-NP response
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• splenocytes from S. mansoni infected mice exposed to soluble schistosome egg antigens in vitro display a type 1 cytokine dominated response with marked elevation of IFNG secretion in contrast to wild-type cells that display a type 2 cytokine response
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• striking reduction in granuloma development in the liver following infection with Schistosoma mansoni and granulomas that do form are virtually devoid of the characteristic eosinophil infiltration present in wild-type controls
(J:60609)
• papain-induced airway eosinophilia is impaired compared to in wild-type mice
(J:165513)
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• striking reduction in granuloma development in the liver following infection with Schistosoma mansoni and granulomas that do form are virtually devoid of the characteristic eosinophil infiltration present in wild-type controls
(J:60609)
• reduced periportal and hepatic fibrosis following infection with Schistosoma mansoni compared to wild-type mice
(J:60609)
• T cells in the intestine have a Th1 like phenotype in S. mansoni infected mice rather than the Th2 like phenotype seen in wild-type mice
(J:60609)
• mice immunized with recombinant vvG (vaccinia virus expressing the G protein of respiratory syncytial virus (RSV)) then challenged with RSV display lower percentages and total numbers of eosinophils in the bronchoalveolar lavage (BAL) compared to wild-type mice
(J:131994)
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• increase in S. mansoni infection induced liver damage measured by plasma aspartate aminotransferase levels compared to wild-type mice
• marked distension and inflammation of the ileum in S. mansoni infected mice and impaired parasite egg excretion compared to wild-type mice
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• increased mortality following acute infection with Schistosoma mansoni compared to wild-type mice
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endocrine/exocrine glands
• delayed lobuloalveolar development
• development improves over gestation
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integument
• delayed lobuloalveolar development
• development improves over gestation
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reproductive system
• delayed lobuloalveolar development
• development improves over gestation
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digestive/alimentary system
• marked distension and inflammation of the ileum in S. mansoni infected mice
• circulating levels of LPS in S. mansoni infected mice are elevated indicating impaired integrity of the gut
• T cells in the intestine have a Th1 like phenotype in S. mansoni infected mice rather than the Th2 like phenotype seen in wild-type mice
|
hematopoietic system
• in an anti-NP response
|
• splenocytes from S. mansoni infected mice exposed to soluble schistosome egg antigens in vitro display a type 1 cytokine dominated response with marked elevation of IFNG secretion in contrast to wild-type cells that display a type 2 cytokine response
|