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Phenotypes Associated with This Genotype
Genotype
MGI:4838174
Allelic
Composition		 Rr156tm6Cog/Rr156tm6Cog
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
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♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
hematopoietic system phenotype ( J:165617 )
N
• proportions of B and T lymphocytes, monocytes and macrophage are about normal
• developmental stages of lymphocytes are present in expected numbers
decreased B cell number ( J:165617 )
• decreased number of B220 cells in the spleen
decreased IgM level ( J:165617 )
• decreased surface expression of IgM on bone marrow B220 cells

immune system
immune system phenotype ( J:165617 )
N
• cell numbers in the spleen are normal
• no effect on class switch recombination
• antigen activation of B cells is normal
decreased B cell number ( J:165617 )
• decreased number of B220 cells in the spleen
decreased IgM level ( J:165617 )
• decreased surface expression of IgM on bone marrow B220 cells

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory