Phenotypes Associated with This Genotype

Genotype
MGI:4838172

• Allelic Composition: Pdpk1^tm1Mlw/Pdpk1^tm1Mlw; Tg(Cd4-cre)1Cwi/0
• Genetic Background: involves: C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

decreased T cell proliferation ( J:165626 )

• T cells are defective in homeostatic proliferation in a lymphopenic host compared with similarly treated wild-type cells

abnormal T cell differentiation ( J:165626 )

• T cell egression from the thymus is impaired compared to in wild-type mice

decreased T cell number ( J:165626 )

• the number of conventional alpha/beta T cells are reduced in the liver, spleen, lymph nodes, and blood compared with wild-type mice

decreased NK T cell number ( J:165626 )

• NK1.1-/CD44- stage 1 cells are decreased 4-fold compared to in wild-type mice

• NK1.1-/CD44- stage 2 and 3 cells are decreased greater than 4-fold compared to in wild-type mice

absent NK T cells ( J:165626 )

• invariant NK T cells are absent from the liver unlike in wild-type mice

• however, mice exhibit normal frequencies of conventional NK cells in the liver

abnormal CD8-positive, alpha beta T cell morphology ( J:165626 )

• CD8+ cells exhibit reduced surface expression of CD8 compared to in wild-type mice

• TCRbeta^high CD8+ single positive thymocytes exhibit a 2-fold reduction in CD8 expression compared with wild-type cells

abnormal NK T cell morphology ( J:165626 )

• invariant NK T cell development is blocked as cells transit stage 1

immune system

immune system phenotype ( J:165626 )

N • thymocyte numbers and the subpopulations are normal

decreased T cell proliferation ( J:165626 )

• T cells are defective in homeostatic proliferation in a lymphopenic host compared with similarly treated wild-type cells

abnormal T cell differentiation ( J:165626 )

• T cell egression from the thymus is impaired compared to in wild-type mice

decreased T cell number ( J:165626 )

• the number of conventional alpha/beta T cells are reduced in the liver, spleen, lymph nodes, and blood compared with wild-type mice

decreased NK T cell number ( J:165626 )

• NK1.1-/CD44- stage 1 cells are decreased 4-fold compared to in wild-type mice

• NK1.1-/CD44- stage 2 and 3 cells are decreased greater than 4-fold compared to in wild-type mice

absent NK T cells ( J:165626 )

• invariant NK T cells are absent from the liver unlike in wild-type mice

• however, mice exhibit normal frequencies of conventional NK cells in the liver

abnormal CD8-positive, alpha beta T cell morphology ( J:165626 )

• CD8+ cells exhibit reduced surface expression of CD8 compared to in wild-type mice

• TCRbeta^high CD8+ single positive thymocytes exhibit a 2-fold reduction in CD8 expression compared with wild-type cells

abnormal NK T cell morphology ( J:165626 )

• invariant NK T cell development is blocked as cells transit stage 1

cellular

decreased T cell proliferation ( J:165626 )

• T cells are defective in homeostatic proliferation in a lymphopenic host compared with similarly treated wild-type cells