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Phenotypes Associated with This Genotype
Genotype
MGI:4838171
Allelic
Composition		 Pdpk1tm1Mlw/Pdpk1tm1.1Daca
Tg(Cd4-cre)1Cwi/0
Genetic
Background		 involves: 129P2/OlaHsd * BALB/c * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pdpk1tm1.1Daca mutation (0 available); any Pdpk1 mutation (141 available)
Pdpk1tm1Mlw mutation (0 available); any Pdpk1 mutation (141 available)
Tg(Cd4-cre)1Cwi mutation (12 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased T cell number ( J:165626 )
• T cells are decreased in the liver compared to in wild-type mice
decreased NK T cell number ( J:165626 )
• NK1.1-/CD44- stage 1 through 3 cells are decreased compared to in wild-type mice
• invariant NK T cell numbers in peripheral tissues (spleen, blood, and liver) is severely decreased compared to in wild-type mice
abnormal CD8-positive, alpha beta T cell morphology ( J:165626 )
• CD8+ thymocytes exhibit reduced surface expression of CD8 compared to in wild-type mice

hematopoietic system
decreased T cell number ( J:165626 )
• T cells are decreased in the liver compared to in wild-type mice
decreased NK T cell number ( J:165626 )
• NK1.1-/CD44- stage 1 through 3 cells are decreased compared to in wild-type mice
• invariant NK T cell numbers in peripheral tissues (spleen, blood, and liver) is severely decreased compared to in wild-type mice
abnormal CD8-positive, alpha beta T cell morphology ( J:165626 )
• CD8+ thymocytes exhibit reduced surface expression of CD8 compared to in wild-type mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory