Phenotypes Associated with This Genotype

Genotype
MGI:4838158

• Allelic Composition: Ccn2^tm2Mae/Ccn2⁺; Tg(EIIa-cre)C5379Lmgd/?
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:165111 )

• Background Sensitivity: no heterozygous embryos after E14.5

embryo

embryonic growth retardation ( J:165111 )

• small and embryonic development is delayed

decreased embryo size ( J:165111 )

cardiovascular system

abnormal vasculogenesis ( J:165111 )

• poor vascularization at E13.5-14.5

vision/eye

abnormal eye development ( J:165111 )

• eye is less developed at E13.5-14.5

craniofacial

short face ( J:165111 )

• shortened face in mice surviving to adulthood (4/81)

facial cleft ( J:165111 )

lateral facial cleft ( J:165111 )

• at E13.5-14.5

midline facial cleft ( J:165111 )

• at E13.5-14.5

small ears ( J:165111 )

• in mice surviving to adulthood (4/81)

limbs/digits/tail

short tail ( J:165111 )

• in mice surviving to adulthood (4/81)

kinked tail ( J:165111 )

• in mice surviving to adulthood (4/81)

skeleton

abnormal bone structure ( J:165111 )

• smaller bone area in mice surviving to adulthood (4/81)

decreased bone mineral content ( J:165111 )

• in mice surviving to adulthood (4/81)

growth/size/body

short face ( J:165111 )

• shortened face in mice surviving to adulthood (4/81)

facial cleft ( J:165111 )

lateral facial cleft ( J:165111 )

• at E13.5-14.5

midline facial cleft ( J:165111 )

• at E13.5-14.5

small ears ( J:165111 )

• in mice surviving to adulthood (4/81)

embryonic growth retardation ( J:165111 )

• small and embryonic development is delayed

decreased embryo size ( J:165111 )

decreased lean body mass ( J:165111 )

• in mice surviving to adulthood (4/81)

hearing/vestibular/ear

small ears ( J:165111 )

• in mice surviving to adulthood (4/81)