Phenotypes for Mcm3 Mcm4 MGI:4838113 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Mcm3^{Gt(RRR002)Byg}/Mcm3⁺ Mcm4^chaos3/Mcm4^{Gt(RRE056)Byg}
Genetic Background	involves: 129P2/OlaHsd * C3HeB/FeJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mcm3^{Gt(RRR002)Byg} mutation (0 available); any Mcm3 mutation (43 available)
Mcm4^chaos3 mutation (1 available); any Mcm4 mutation (43 available)
Mcm4^{Gt(RRE056)Byg} mutation (0 available); any Mcm4 mutation (43 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:165667 )

• mice die sooner than Mcm4^chaos3 homozygotes

postnatal lethality, incomplete penetrance ( J:165667 )

• postnatal mortality observed in Mcm4^chaos3/Mcm4^{Gt(RRE056)Byg} mice is partially rescued

neoplasm

increased mammary gland tumor incidence ( J:165667 )

increased lymphoma incidence ( J:165667 )

endocrine/exocrine glands

increased mammary gland tumor incidence ( J:165667 )

integument

increased mammary gland tumor incidence ( J:165667 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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