Mouse Genome Informatics
ht
    Ass1bar/Ass1fold
involves: C57BL/6Ei * C57BL/6J * OF1 * P/J
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging

growth/size

behavior/neurological
• unstable gait

homeostasis/metabolism
• P14 and P21 mice show a 10- to 40-fold increase in the levels of citrulline, and a 1.5- to threefold increase in the plasma levels of many amino acids, including glutamine, cystine, methionine, and lysine and lysine and arginine, glutamic acid, leucine, and ornithine levels are decreased
• Plasma ammonia concentration at P14 is elevated
• argininosuccinate synthetase 1 activity is significantly decreased in liver

nervous system
• granule cell migration appears to be delayed by several days

integument
• enough hair grows in by 3 weeks of age for a sparse coat
• follicular dystrophy

cellular
• granule cell migration appears to be delayed by several days

Mouse Models of Human Disease
OMIM IDRef(s)
Citrullinemia, Classic 215700 J:165341