Phenotypes Associated with This Genotype

Genotype
MGI:4838048

• Allelic Composition: Sh2d3c^tm1.1Ebp/Sh2d3c^tm1.1Ebp
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, incomplete penetrance ( J:164874 , J:165694 )

• most mice die in the first day after birth (J:165694)

• however, mice that survive shortly after birth exhibit normal survival (J:165694)

reproductive system

small testis ( J:164874 )

♂ • greatly in 3 of 8 surviving adult male mice

nervous system

abnormal axon extension ( J:164874 )

• olfactory neurons grown in 3 dimensional extracellular matrix exhibit reduced outgrowth compared with similarly treated wild-type neurons

abnormal hypothalamus morphology ( J:164874 )

• at P0.5, fewer gonadotropin positive cells are found in the preoptic region of the hypothalamus compared to in wild-type mice

abnormal olfactory bulb layer morphology ( J:164874 )

• olfactory bulbs exhibit severe defects in lamination compared with wild-type

• the nerve fiber layer is completely lost unlike in wild-type mice

abnormal olfactory bulb glomerular layer morphology ( J:164874 )

• mice exhibit a lack of the stereotypic circular arrangement of interneurons in the glomerular layer unlike wild-type mice

abnormal olfactory bulb mitral cell layer morphology ( J:164874 )

• mice lack a distinct mitral cell layer unlike in wild-type mice

olfactory bulb hypoplasia ( J:164874 )

• in 23 of 25 mice at P0.5

abnormal sensory neuron morphology ( J:164874 )

• by E13.5, olfactory sensory neuron axons exhibit impaired ability to reach the developing olfactory bulb stalling outside the pial basement membrane unlike in wild-type mice

abnormal sensory neuron innervation pattern ( J:164874 )

• by E13.5, olfactory sensory neuron axons exhibit impaired ability to reach the developing olfactory bulb stalling outside the pial basement membrane unlike in wild-type mice

abnormal olfactory nerve morphology ( J:164874 )

• at P0.5, mice exhibit deficient innervation in the olfactory bulb compared with wild-type mice

abnormal nervous system physiology ( J:164874 )

• at P0.5, the olfactory bulb exhibits increased apoptosis in the epithelium compared to in wild-type mice

• however, no increase in apoptosis is observed at E14.5

behavior/neurological

absent gastric milk in neonates ( J:165694 )

• in most mice

endocrine/exocrine glands

small testis ( J:164874 )

♂ • greatly in 3 of 8 surviving adult male mice

cellular

abnormal axon extension ( J:164874 )

• olfactory neurons grown in 3 dimensional extracellular matrix exhibit reduced outgrowth compared with similarly treated wild-type neurons