Phenotypes Associated with This Genotype

Genotype
MGI:4837860

• Allelic Composition: Apoe^tm1Unc/Apoe^tm1Unc; Nos2^tm1Mrl/Nos2^tm1Mrl
• Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:64566 )

N • no effect on plasma cholesterol, triglycderide, or nitrate levels when compared to Apoe^tm1Unc controls on any diet tested

decreased cholesterol level ( J:64566 )

• total cholesterol in the aorta is reduced 40% in males and 50% in females

• free cholesterol in the aorta is reduced 40% in males and 50% in females

• cholesterol ester in the aorta is reduced 57% in males and 72% in females

growth/size/body

increased body weight ( J:64566 )

• females are slightly heavier than controls

• no weight effect in males

cardiovascular system

atherosclerotic lesions ( J:64566 )

• lesions are smaller and flatter

• male lesions are 50% smaller

• female lesions are 30% smaller