Phenotypes Associated with This Genotype

Genotype
MGI:4837536

• Allelic Composition: Tlr8^tm1Vlcg/Tlr8^tm1Vlcg
• Genetic Background: B6.129S1-Tlr8^tm1Vlcg

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

enlarged spleen ( J:165267 )

♀ • with expansion of the CD11c+ and CD19+ populations but decrease in dendritic cell and marginal zone B cells

increased spleen weight ( J:165267 )

♀

decreased dendritic cell number ( J:165267 )

♀ • in the spleen

decreased B-1a cell number ( J:165267 )

♀

decreased B-1b cell number ( J:165267 )

♀

increased B-2 B cell number ( J:165267 )

♀

abnormal spleen marginal zone morphology ( J:165267 )

♀

decreased marginal zone B cell number ( J:165267 )

♀ • peripheral to follicles

decreased IgG1 level ( J:165267 )

♀

increased IgG level ( J:165267 )

♀ • as glomerular deposition, but not in the serum

increased IgG2a level ( J:165267 )

♀

increased IgM level ( J:165267 )

♀ • in the serum and as glomerular deposition

increased circulating interleukin-12 level ( J:165267 )

♀ • in bone marrow-derived dendritic cells, total splenocytes, and splenic dendritic cells stimulated with R848, polyA:U, and any TLR7 ligand tested secrete more IL12b (IL-12p40) than similarly treated wild-type cells

♀ • however, response to pCpG, polyI:C, and LPS is normal and serum level in R848-treated mice is normal

increased interleukin-6 secretion ( J:165267 )

♀ • in bone marrow-derived dendritic cells, total splenocytes, and splenic dendritic cells stimulated with R848, polyA:U, and any TLR7 ligand tested

♀ • however, response to polyI:C and LPS is normal and serum level in R848-treated mice is normal

increased anti-nuclear antigen antibody level ( J:165267 )

♀ • mice exhibit an increase in IgG autoantibodies smRNP, RNP, and dsDNA compared with wild-type mice

increased anti-double stranded DNA antibody level ( J:165267 )

♀

glomerulonephritis ( J:165267 )

♀ • mice exhibit increased deposition of IgM, IgG, and C3 in the glomerulus compared with wild-type mice

renal/urinary system

glomerulonephritis ( J:165267 )

♀ • mice exhibit increased deposition of IgM, IgG, and C3 in the glomerulus compared with wild-type mice

renal glomerular immunoglobulin deposits ( J:165267 )

♀

homeostasis/metabolism

increased circulating interleukin-12 level ( J:165267 )

♀ • in bone marrow-derived dendritic cells, total splenocytes, and splenic dendritic cells stimulated with R848, polyA:U, and any TLR7 ligand tested secrete more IL12b (IL-12p40) than similarly treated wild-type cells

♀ • however, response to pCpG, polyI:C, and LPS is normal and serum level in R848-treated mice is normal

hematopoietic system

enlarged spleen ( J:165267 )

♀ • with expansion of the CD11c+ and CD19+ populations but decrease in dendritic cell and marginal zone B cells

increased spleen weight ( J:165267 )

♀

decreased dendritic cell number ( J:165267 )

♀ • in the spleen

decreased B-1a cell number ( J:165267 )

♀

decreased B-1b cell number ( J:165267 )

♀

increased B-2 B cell number ( J:165267 )

♀

abnormal spleen marginal zone morphology ( J:165267 )

♀

decreased marginal zone B cell number ( J:165267 )

♀ • peripheral to follicles

decreased IgG1 level ( J:165267 )

♀

increased IgG level ( J:165267 )

♀ • as glomerular deposition, but not in the serum

increased IgG2a level ( J:165267 )

♀

increased IgM level ( J:165267 )

♀ • in the serum and as glomerular deposition

growth/size/body

enlarged spleen ( J:165267 )

♀ • with expansion of the CD11c+ and CD19+ populations but decrease in dendritic cell and marginal zone B cells

increased spleen weight ( J:165267 )

♀