Phenotypes Associated with This Genotype

Genotype
MGI:4837351

• Allelic Composition: Robo3^tm1Matl/Robo3^tm1Matl
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:165285 )

• within 8 hours of birth

nervous system

abnormal pre-Botzinger complex physiology ( J:165285 )

• at E15.5, rhythmic activity frequency in the pre-Botzinger complex is lower than in wild-type mice

• at E15.5, bilateral synchronization of rhythmic activity in the pre-Botzinger complex is absent unlike in wild-type mice

respiratory system

abnormal breathing pattern ( J:165285 )

• at P0, mice exhibit independent left and right rhythmic contractions of the diaphragm unlike wild-type mice

homeostasis/metabolism

cyanosis ( J:165285 )